The Neurodegenerative Disease Research Center (NDRC) at University of Science and Technology of China(USTC) is devoted to combining basic research on mechanisms of cognition and neuron functions in the healthy brain with brain disorders. Our discoveries are laying the foundation for better understanding and treatments of various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Cerebral vascular disease. The translational research approaches take advantages of the basic science discoveries in brain disorders to translate advances in the laboratories efficiently and rapidly into diagnosis, technologies and therapies for patients, their families, their friends and their communities.

The mission of the NDRC is to promote and accelerate the transfer of basic science discoveries to clinical medical practice. The NDRC creates and supports multidisciplinary programs that help bring the discoveries of the laboratory to clinical applications, offering a unique training ground for pre- or/and medical students and post-doctoral/medical fellows. It provides support for the following research programs in the NDRC at USTC:

● Investigation of cell process underlying neuron death or dysfunctions using cell culture and animal models.

● Elucidation of new molecular pathways of neurodegeneration and neuron survival and discovery of novel therapies.

● Molecular dissection of inflammatory elements that affect neurodegeneration or survival.

● Identification of biomarkers for early diagnosis of the brain disorders and monitoring efficacy of the clinical trials.

● Examination of new technologies, including single cell sequencing and mass spectrometry, for identification of new genes and proteins for the brain disorders.

● Developing new bio-assay systems to effectively screen potential drugs, including small molecule chemical compounds as well as herbal medicines.

● Clinical trials to treat the brain disorders.