视觉修复与再生实验室
薛天 博士
图书馆VIP生命科学学院教授，博士生导师
国家杰出青年科学基金获得者
国家自然科学基金优秀青年基金获得者
1995-2000 图书馆VIP少年班（强化班），学士学位
2000-2005 美国约翰霍普金斯大学医学院，分子生理学博士学位
2006-2011 美国约翰霍普金斯大学医学院神经学系，博士后
2011-2012 美国约翰霍普金斯大学医学院神经学系，助理研究员
2013-至今 图书馆VIP教授
2015-至今 图书馆VIP生命学院执行院长
主要研究领域及学术业绩：
长期从事光感受细胞的光信号转导和神经环路以及干细胞相关的感光细胞再生等研究；在神经推行疾病如AD研究方面，拟建立视网膜作为阿尔兹海默症检测新模型；试图通过现有的眼科检测技术检验是否可以在视网膜上快速而准确地检测到AD相关病理，包括β-淀粉样蛋白的沉积以及血管异常等，为临床上AD的诊断和治疗提供新的手段。目前共发表SCI论文25篇，多篇第一或通讯作者论文发表在Nature、Nature Neuroscience、Circulation、Circulation Research、Stem cells等学术期刊，引用次数达1000余次。
1. Akhtar T, Xie H, Khan MI, Zhao H, Bao J, Zhang M, Xue T, Accelerated photoreceptor differentiation of hiPSC derived retinal organoids by contact co-culture with retinal pigment epithelium. Stem Cell Res. 2019 Jul 2;39:101491.
Cai Y, Cheng T, Yao Y, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M, Qiu Z, Xue T, In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Sci Adv. 2019 Apr 17;5(4):eaav3335.
2. Ma Y, Bao J, Zhang Y, Li Z, Zhou X, Wan C, Huang L, Zhao Y, Han G, Xue T, Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell. 2019 Apr 4;177(2):243-255.e15.
Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J, Zheng G, Nanowire arrays restore vision in blind mice. Nat Commun. 2018 Mar 6;9(1):786.
3. Hu QX, Dong JH, Du HB,Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP （2014） Constitutive Gαi Coupling Activity of VLGR1 and itsRegulation by PDZD7. J Biol Chem 289(35):24215-2
4. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T,Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014).Human-iPSC-Derived, 3-Dimensional Retinal Cups with Functional Photoreceptors. Nature Communication:4047.
5. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE,Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T,Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA,Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A,
6. Nickells RW,Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. (2013). Functional genomicscreening identifies dual leucine zipper kinase as a key mediator of retinalganglion cell death.Proc NatlAcad Sci U S A. 110(10):4045-50.
7. Xue T¶, Do MT, Riccio A,Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P,Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW¶. (2011).Melanopsin Signaling in Mammalian Iris and Retina. Nature. 479(7371):67-73. (Research Article) (¶co-corresponding authors); Faculty of 1000: f1000.com/13360986.
8. Xue T, Siu CW, Lieu DK, LauCP, Tse HF, Li RA. (2007) Mechanistic role of I(f) revealed by induction ofventricular automaticity by somatic gene transfer of gating-engineeredpacemaker (HCN) channels. Circulation.115(14):1839-1850.
纳米技术增强小鼠视力
在体精准基因治疗和视觉修复
